GE02: Genetic-epidemiologic research methods

Week 1, 24 -- 28 Oct. 2005, Binary traits in families and populations

Exercises are available at http://mga.bionet.nsc.ru/ge02-2005/program.html

Day 1

Part 1.I: Basic probability, Mendel's lows

Part 1.II: Population genetics, Hardy-Weinberg equilibrium, departures from HWE

Part 1.III: Inbreeding

Day 2

Part 2.I: Mutation-selection balance

Part 2.II: Binomial distribution

Part 2.III: Genetic drift

Part 2.IV: Normal approximation to Binomial

Day 3

Part 3.I: Hypothesis testing

Part 3.II: Not independent events, Bayes theorem, relative and absolute risk

Day 4

Part 4.I: Genetic risk calculation in families: X-linked and dominant disease

Part 4.II: Genetic risk calculation in families: recessive disease

Part 4.III: Classical & complex segregation analysis

Part 4.IV: Power of genetic-epidemiological study