- Color-blindness ( from Feller, Ch.5, Ex. 7).
Let us assume that the frequencies of color-blindness are 5% and 0.25%
of in men and women, respectively.
What is the chance that a given color-blind person is a man?
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Let in population there are 2 alleles, M and N.
Frequency of M, P(M)=0.1
Penetrances (conditional probability of having disease given genotype) are
P(D|MM)=0.4, P(D|MN)=0.1, P(D|NN)=0.03.
- What is disease frequency in the population?
- What is frequency of mutant allele, M, in disease cases?
- What is frequency of mutant allele, M, in healthy people?