1. Color-blindness ( from Feller, Ch.5, Ex. 7). Let us assume that the frequencies of color-blindness are 5% and 0.25% of in men and women, respectively. What is the chance that a given color-blind person is a man?
  2. Let in population there are 2 alleles, M and N. Frequency of M, P(M)=0.1 Penetrances (conditional probability of having disease given genotype) are P(D|MM)=0.4, P(D|MN)=0.1, P(D|NN)=0.03.
    1. What is disease frequency in the population?
    2. What is frequency of mutant allele, M, in disease cases?
    3. What is frequency of mutant allele, M, in healthy people?