Plan to spend 1.5 hours on HWE

1. Consider a locus with two alleles, A and B. The frequency of allele A is 0.36. What are the frequencies of AA, AB and BB genotypes under Hardy-Weinberg equilibrium? Answer
2. Consider a locus with two alleles, A and B. The frequency of allele A is 0.16. What are the frequencies of AA, AB and BB genotypes under Hardy-Weinberg equilibrium? Answer
3. Consider a locus with 5 alleles (named from A_1 to A_5). The frequency of allele A_1 ... A_4 are 0.1666, 0.7158, 0.0473, 0.0616, respectively. What are the frequencies of A_1/A_1, A_1/A_2, ... A_5/A_5 genotypes under Hardy-Weinberg equilibrium? Answer
4. A study population is a 3:1 mixture of population A and population B. Frequncy of the allele of interest is 0.1 in population A and 0.2 is population B. Both populations are under HWE.
   1. What is allelic frequency in the mixed population? Answer
   2. What is genotypic distribution in the mixed population? Answer
   3. What genotypic frequencies would be expected under HWE? Answer Is it likely that the deviation from HWE due to Wahlund's effect will be detected?
5. In a large population, average inbreeding is 0.03. For a variant with frequency of 0.01, compute HWE frequencies with and without assumption of inbreeding. Answer Is it likely that the deviation from HWE due to inbreeding will be detected?