GE02: Genetic-epidemiologic research methods

Week 1, 16 -- 20 Oct. 2006, Binary traits in families and populations

Exercises with answers are available at http://mga.bionet.nsc.ru/~yurii/courses/ge02-2006/program.html

Day 1

Part 1.I: Basic probability

Part 1.II: Independent events, Mendel's lows

Part 1.III: Population genetics, Hardy-Weinberg equilibrium

Part 1.IV: Departure from HWE, Wahlund's effect, Inbreeding

Day 2

Part 2.I: Mutation-selection balance

Part 2.II: Binomial distribution

Part 2.III: Genetic drift

Part 2.IV: Normal approximation to Binomial

Day 3

Part 3.I: Hypothesis testing

Part 3.II: Power of genetic-epidemiological study

Part 3.III: Conditional probability, total probability

Part 3.VI: Bayes formula, realtiveand absolute risk

Day 4

Part 4.I and 4.II: Genetic risk calculation in families: X-linked and dominant disease

Part 4.III: Genetic risk calculation in families: recessive disease

Part 4.VI: Classical segregation analysis

Day 5

Part 5.I: Complex segregation analysis

Part 5.II: Genetic data Quality Control

Part 5.III: Introduction to Linkage analysis