Plan to spend 45 minutes on HWE

1. STANDARD Consider a locus with two alleles, A and B. The frequency of allele A is 0.36. What are the frequencies of AA, AB and BB genotypes under Hardy-Weinberg equilibrium? Answer
2. STANDARD Consider a locus with two alleles, A and B. The frequency of allele A is 0.16. What are the frequencies of AA, AB and BB genotypes under Hardy-Weinberg equilibrium? Answer
3. STANDARD Consider a locus with 5 alleles (named from A_1 to A_5). The frequency of allele A_1 ... A_4 are 0.1666, 0.7158, 0.0473, 0.0616, respectively. What are the frequencies of A_1/A_1, A_1/A_2, ... A_5/A_5 genotypes under Hardy-Weinberg equilibrium? Answer
4. MEDIAN Consider a biallelic SNP with alleles T and G. The frequency of T in the population is 0.2. The SNP is located at X-chromosome. Males have only one X-chromosome and thus could have genotype T (which can not be distinguished from TT) or G (which can not be distinguished from GG). Assuming that population consist of 50% men and 50% women, what genotypic proprtions are expected?