GE02: Genetic-epidemiologic research methods
Week 1, Oct. 20 -- 24, 2008. Binary traits in families and populations
Day 1
Introduction
Slides
Slides for students
Basic probability
Slides
Slides for students
Supplementary Excel files
Supplementary data
Exercises
Notes
Audio
Independent events, Mendel's lows
Slides
Slides for students
Supplementary Excel files
Exercises
Notes
Audio
Population genetics, Hardy-Weinberg equilibrium
Slides
Slides for students
Supplementary Excel files
Exercises
Notes
Audio
Departure from HWE, Genotyping error, Wahlund's effect, Inbreeding
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Slides for students
Supplementary Excel files
Exercises
Notes
Audio
Answers
Day 2
Conditional probability, total probability
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Slides for students
Supplementary Excel files
Exercises
Notes
Bayes formula, realtive and absolute risk
Slides
Slides for students
Supplementary Excel files
Exercises
Notes
Mutation-selection balance
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Slides for students
Supplementary Excel files
Exercises
Notes
Audio
Answers
Day 3
Genetic risk calculation in families:
X-linked and dominant disease
Slides
Old HTML
Slides for students
Supplementary Excel files
Exercises
Supplementary Data
Notes
Genetic risk calculation in families:
recessive disease
Slides
Slides for students
Supplementary Excel files
Exercises1
Exercises2
Answers
Notes
Day 4
Binomial distribution
Slides
Slides for students
Supplementary Excel files
Exercises
Notes
Genetic drift
Slides
Slides for students
Supplementary Excel files
Exercises
Supplementary data
Answers
Notes
Normal & Poisson approximations to Binomial
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Slides for students
Supplementary Excel files
Exercises
Supplementary data
Notes
Answers
Day 5
Hypothesis testing
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Slides for students
Supplementary Excel files
Exercises
Answers
Notes
Statistical testing in genetic-epidemiological studies
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Slides for students
Supplementary Excel files
Exercises
Answers
Notes
Power of genetic-epidemiological study
Slides
Slides for students
Supplementary Excel files
Exercises
Supplementary data
Notes
Answers