The frequency of carriers is 0.00076. As the frequency is low, we may neglect the frequency of homozygous carriers and thus consider that only heterozygous carriers are observed. Given the frequency of disease allele is q, the frequency of carriers is 2 q (1-q) = 0.00076 Neglecting q^2 term, 2 q = 0.00076 => q = 0.00038 Given the slection pressure is 0.7 (it is one minus survival), from formula q^2 = mu/s we may find mu mu = s q^2 mu = 0.7 * 0.00038 * 0.00038 = 1.0108E-007