Plan to spend about 20 minutes on this exercise

  • A study population is a 3:1 mixture of population A and population B. Frequncy of the allele of interest is 0.1 in population A and 0.2 is population B. Both populations are under HWE.
    1. STANDARD What is allelic frequency in the mixed population? Answer
    2. STANDARD What is genotypic distribution in the mixed population? Answer
    3. STANDARD What genotypic frequencies would be expected under HWE in the mixed population? Answer
    4. MEDIAN Is it likely that the deviation from HWE due to Wahlund's effect can be detected? (the question is related to power question later on).
  • STANDARD In a large population, average inbreeding is 0.03. For a variant with frequency of 0.01, compute HWE frequencies with and without assumption of inbreeding. Answer Is it likely that the deviation from HWE due to inbreeding can be detected?