GE02: Genetic-epidemiologic research methods
Week 1, Oct. 22 -- 26, 2007. Binary traits in families and populations
Thanks to all participants of GE02-2007 -- it was pleasure to
work with you, and next generations should appreciate the fact
that you picked up so many of errors in my slides. The corrected
slides are here.
Please check if you agree with my rating of the difficulty of the
exercises (I also fixed the exercises according to your comments).
Remember, this is estimated difficulty after all course was done --
not the difficulty level you were experiencing in the class!
If you do not agree with my rating -- drop me an e-mail. You
remember that I am going to score the exams based on this "difficulty
level"...
Day 1
Introduction
Slides
Slides for students
Basic probability
Slides
Slides for students
Supplementary Excel files
Supplementary data
Exercises
Notes
Audio
Independent events, Mendel's lows
Slides
Slides for students
Supplementary Excel files
Exercises
Notes
Audio
Population genetics, Hardy-Weinberg equilibrium
Slides
Slides for students
Supplementary Excel files
Exercises
Notes
Audio
Departure from HWE, Genotyping error, Wahlund's effect, Inbreeding
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Slides for students
Supplementary Excel files
Exercises
Notes
Audio
Answers
Day 2
Conditional probability, total probability
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Slides for students
Supplementary Excel files
Exercises
Notes
Bayes formula, realtive and absolute risk
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Supplementary Excel files
Exercises
Notes
Mutation-selection balance
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Supplementary Excel files
Exercises
Notes
Audio
Answers
Day 3
Genetic risk calculation in families:
X-linked and dominant disease
Slides
Old HTML
Slides for students
Supplementary Excel files
Exercises
Supplementary Data
Notes
Genetic risk calculation in families:
recessive disease
Slides
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Supplementary Excel files
Exercises1
Exercises2
Answers
Notes
Day 4
Binomial distribution
Slides
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Supplementary Excel files
Exercises
Notes
Genetic drift
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Supplementary Excel files
Exercises
Supplementary data
Answers
Notes
Normal & Poisson approximations to Binomial
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Supplementary Excel files
Exercises
Supplementary data
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Day 5
Hypothesis testing
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Exercises
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Notes
Statistical testing in genetic-epidemiological studies
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Supplementary Excel files
Exercises
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Notes
Power of genetic-epidemiological study
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Slides for students
Supplementary Excel files
Exercises
Supplementary data
Notes
Answers