Purpose

To map QTL in model organisms using a data coming from backcrosses. For other analyses see 'modifications.txt'.

Difference from Mapmaker/QTL

There are 2 main differences from MAPMAKER/QTL (M/Q)

1. Our program allows introducing iteractions between genes (epistasis) into a model with ease.
2. It allows estimation LODs significance level given the sample and markers genotyped.
3. While the M/Q uses EM-algorithm, which is model-dependent, our program uses model-independent maximization procedure METHGI (see METHGI documentation). Therefore our program let make an estimates of parameters for a wider range of models.

Availability

The program is available for free here. For now, the realization for DOS/Win95/98/NT is available. Given the source, it easy to port the program to UNIX. This requires only a modification in a character input and random numbers format.

Description

• Two main files of input data arer qtl-map.par and the one noted at the first line of qtl-map.par.
• The first one provides a data to make analysis (see description inside).
• The second one provides a model to maximixe.
• The third line provides a name of file to make output to.
• The forth -- number of trait to analyse (i2)
• The fith --- number of genes to fix [0,2]
• The sixsth and seventh -- the group of linkage and position of genes to fix the position.

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Yurii Aulchenko,
Institute of Cytology and Genetics,
630090, Novosibirsk, RUSSIA
e-mail: yurii@bionet.nsc.ru
web: http://mga.bionet.nsc.ru